近年来，mRNA技术凭借快速响应、灵活设计等优势，从疫苗研发扩展至肿瘤免疫、基因编辑等前沿领域，全球市场规模预计2025年突破千亿美元。然而，?核酸稳定性低、靶向递送难、工艺成本高?三大痛点仍制约其临床转化效率。

作为纳米药物递送系统平台的先行者，已成功为国内多家知名药企提供高精度递送方案。基于此，锘海正式推出?mRNA全链研发解决方案?：mRNA 核酸系列产品、脂质纳米粒试剂盒以及核酸定制、核酸包封及方案技术支持服务。通过标准化产品与定制化服务双轨并行。助力科研机构突破递送瓶颈，推动实验室成果向临床转化。从原料供应到工艺优化，从设备支持到方案设计，锘海正以全链条服务能力赋能mRNA药物研发，加速国产高端科研设备在生物医药领域的深度应用。

 mRNA 核酸系列产品 

锘海提供四十余种核酸产品，广泛应用于生物医药等领域，可高效表达目标基因。

EGFP mRNA 转染间充质干细胞 24小时

EGFP mRNA 转染原代单核细胞 24小时

 FlowOrigin M 脂质纳米粒试剂盒 

为解决合成核酸脂质纳米粒（LNP）时遇到的问题（如浓度、配比、配制环境、体积等），预制了所需的所有原料（核酸除外），使得客户能够在设计好所需的核酸后，即可进行载体包裹，并进行体内或体外实验，加速实验进程、提升项目评估的准确性。

                                                                                                                                              FlowOrigin M 脂质纳米粒试剂盒                                                       试剂盒转染效果

                                                                                                                                                                Cre mRNA 转染LoxP-tdtomato小鼠皮肤细胞              mCherry-mRNA转染骨髓间充质干细胞                                Luc mRNA体内活体成像

  核酸定制、核酸包封及方案技术支持服务  

 应用文献 

1. Human adipose-derived multipotent stromal cells enriched with IL-10 modRNA improve diabetic wound healing: Trigger the macrophage phenotype shift. Bioeng Transl Med. 2024; e10711.

2. Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection. Signal Transduct Target Ther. 2024 Jun 21;9(1):150. 

3. ROS-Responsive Injectable Hydrogel Loaded with SLC7A11-modRNA Inhibits Ferroptosis and Mitigates Intervertebral Disc Degeneration in Rats. Adv Healthc Mater. 2024 May 1:e2401103.

4. Sustained delivery of chemically modified mRNA encoding amelogenin from selfassembling hydrogels for periodontal regeneration.  Composites Part B: Engineering.Available online 21 December 2023, 111162.

5. Adipose-derived stem cells enriched with therapeutic mRNA TGF-β3 and IL-10 synergistically promote scar-less wound healing in preclinical models. Bioeng Transl Med. 2023 Nov 10;9(2):e10620. 

6. Vascular endothelial growth factor a modified mRNA engineered cellular electrospun membrane complexes promotes mouse skin wound repair. Materials Today Bio. 2023 Aug 23;22:100776.

7. Enhanced adipose-derived stem cells with IGF-1-modified mRNA promote wound healing following corneal injury. Mol Ther. 2023 Aug 2;31(8):2454-2471. 

8. Safe and Effective Delivery of mRNA Using Modified PEI-Based Lipopolymers. Pharmaceutics. 2023 Jan 26;15(2):410. 

9. Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis, Biomater Res . 2023 Jan 17;27(1):3. 

10. Transient secretion of VEGF protein from transplanted hiPSC-CMs enhances engraftment and improves rat heart function post MI, Molecular Therapy . 2023 Jan 4;31(1):211-229.

11. Combination of chemically modified SDF-1α mRNA and small skin improves wound healing in diabetic rats with full thickness skin defects. Cell Prolif. 2022 Dec;55(12):e13318. 

12. Engineered adipose-derived stem cells with IGF-1-modified mRNA ameliorates osteoarthritis development. Stem Cell Res Ther 2022 Jan 15;13(1):19. 

13. Chemically Modified SDF-1α mRNA Promotes Random Flap Survival by Activating the SDF-1α/CXCR4 Axis in Rats. Front. Cell Dev. Biol. 2021 Feb 4; 9:623959.

14. BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways. Commun Biol. 2021 Jan 19;4(1):82

15. Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model. Stem Cell Res Ther. 2020 Nov 19;11(1):490. 

16. Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. J Control Release. 2019 Sep 28;310:103-114.

17. Lipid nanoparticle-assisted miR29a delivery based on core-shell nanofibers improves tendon healing by cross-regulation of the immune response and matrix remodeling. Biomaterials. Volume 291, 2022, 121888.

18. Enhanced human adipose-derived stem cells with VEGFA and bFGF mRNA promote stable vascular regeneration and improve cardiac function following myocardial infarction. Clin Transl Med. 2025 Mar;15(3):e70250.

随着纳米技术的不断发展，纳米药物在医药领域的应用越来越广泛，尤其在基因治疗，肿瘤靶向等方面显现了不可替代的优势。锘海生物科学为科研工作者和企业提供全面的纳米药物制备、生产及检测服务，囊括了纳米药物研发过程中，从处方筛选到制剂表征的全线过程。为客户简化流程，节约时间成本，同时提供高质量的数据分析与技术支持服务。

◆ 纳米颗粒制备 ◆

客户确定载体和API以及已有的制备protocol，锘海为您提供纳米制剂制备服务，同时检测颗粒的粒径和包封率。

◆ 科研课题外包 ◆

针对科研客户，锘海提供相关课题的完全外包服务。根据您选择的载体和API，帮助您优化和确定处方并完成制备纳米制剂，提供检测报告和protocol。利用锘海纳米制备核心技术平台，提供一站式服务，让您花同样的时间得到多的结果，减少由于技术瓶颈和人员变化带来的实验波动。助您在短的时间，发出高分的文章！

◆ 企业研发与生产 ◆

针对企业客户，锘海提供从载体选择到纳米制剂制备服务。从载体的筛选，处方优化，以及扩大生产（cGMP级别）锘海提供完整的解决和服务方案。缩短研发项目周期，减少科研与生产人力成本，解决无法扩大生产的技术瓶颈！